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排序方式: 共有2245条查询结果,搜索用时 500 毫秒
81.
Giulia Cancian Gianluca Tozzi Amirul Ashraf Bin Hussain Arianna De Mori Marta Roldo 《Journal of materials science. Materials in medicine》2016,27(8):126
Age related bone diseases such as osteoporosis are considered among the main causes of reduced bone mechanical stability and bone fractures. In order to restore both biological and mechanical function of diseased/fractured bones, novel bioactive scaffolds that mimic the bone structure are constantly under development in tissue engineering applications. Among the possible candidates, chitosan-based thermosensitive hydrogel scaffolds represent ideal systems due to their biocompatibility, biodegradability, enhanced antibacterial properties, promotion of osteoblast formation and ease of injection, which makes them suitable for less invasive surgical procedures. As a main drawback, these chitosan systems present poor mechanical performance that could not support load-bearing applications. In order to produce more mechanically-competent biomaterials, the combined addition of hydroxyapatite and carbon nanotubes (CNTs) is proposed in this study. Specifically, the aim of this work is to develop thermosensitive chitosan hydrogels containing stabilised single-walled and multi-walled CNTs, where their effect on the mechanical/physiochemical properties, calcium deposition patterns and ability to provide a platform for the controlled release of protein drugs was investigated. It was found that the addition of CNTs had a significant effect on the sol–gel transition time and significantly increased the resistance to compression for the hydrogels. Moreover, in vitro calcification studies revealed that CNTs played a major role in the spatial arrangements of newly formed calcium deposits in the composite materials studied, suggesting that they may have a role in the way the repair of fragile and/or fractured bones occurs in vivo. 相似文献
82.
Enrique Costa-Montenegro Ana Belén Barragáns-Martínez Marta Rey-López 《Expert systems with applications》2012,39(10):9367-9375
Users face the information overload problem when downloading applications in markets. This is mainly due to (i) the increasing unmanageable number of applications and (ii) the lack of an accurate and fine-grained categorization of the applications in the markets. To address this issue, we present an integrated solution which recommends to the users applications by considering a big amount of information: that is, according to their previously consumed applications, use pattern, tags used to annotate resources and history of ratings. We focus this paper on the service for monitoring users’ interaction. 相似文献
83.
Colour changes of a thermochromic liquid crystal (TLC) ink printed on a black substrate are clearly observed by the naked eye, and therefore it is reasonable to expect that every approach recommended for colour measurements of samples with solid colour would be appropriate. In addition, the published spectroscopic analyses of TLC inks do not provide any guidance or limitations for the measurement geometry. On the other hand, our study demonstrates that spectroscopic measurements of such samples are not so straightforward. When using the most simple and commonly used measurement equipment with a directional illumination and viewing approach, the temperature-dependent spectral features resolve in a narrow spectral region that gives only a small part of the colour play effect. Detection of the entire effect requires the use of integrating spheres, which spatially integrate the radiant flux reflected on a sample in any direction; better results are obtained by spheres of larger diameter. The comparision of spectroscopic and colorimetric results obtained when different measurement geometries are applied on the same sample may demonstrate certain properties of the liquid crystal material inside microcapsules and help in understanding some details of the optical properties of the ink layer. 相似文献
84.
Marek Choratzy ;Marta Majcher ;Katarzyna Fedyszyn Urbanowicz ;Jedrzej Gtasek ;Maciej Gawlikowicz ;Tomasz Duniec 《材料科学与工程:中英文B版...》2014,(12):376-384
The authors compared their earlier results of the tumor biopsies performed under computer tomography (CT) guidance against the results of their recently modified-combined method of visualization and measurement of lung tumor parameters by CT imaging followed by US guided biopsy. In 238 (6.36%) of 3,745 patients in CT examination, the lung tumor was located peripherally, and obtaining histopathological confirmation was crucial to start the proper treatment. The patients were divided into two groups, the division was based on the biopsy method. Within the first group in I 18 patients, parietal lung tumor was confirmed and CT guided biopsy was performed. Within the second group, parietal lung tumor was confirmed in 120 patients and combined method of CT pre- biopsy planning and US guided biopsy were used. Pre-biopsy planning was performed using CT, measurements such as depth and distance of the tumor were made, obtained data were then saved on CT image and patient's skin was marked. Then obtained results were analyzed using test for two proportions. The analysis of the results confirmed the higher efficacy of the combined method taking into account the number of complications (p 〈 0.01) and diagnostic histopathological results (P 〈 0.001). Suggested innovative method, involving both CT pre-biopsy planning and US guided biopsy, allows to analyze simultaneously static CT and dynamic US images and it is considered to be an easy and effective method comparing to relying on static in nature CT images only. Our method is related to a lower complication risk rate. 相似文献
85.
Hugo Plácido da Silva André Lourenço Ana Fred Nuno Raposo Marta Aires-de-Sousa 《Computer methods and programs in biomedicine》2014
The Check Your Biosignals Here initiative (CYBHi) was developed as a way of creating a dataset and consistently repeatable acquisition framework, to further extend research in electrocardiographic (ECG) biometrics. In particular, our work targets the novel trend towards off-the-person data acquisition, which opens a broad new set of challenges and opportunities both for research and industry. While datasets with ECG signals collected using medical grade equipment at the chest can be easily found, for off-the-person ECG data the solution is generally for each team to collect their own corpus at considerable expense of resources. In this paper we describe the context, experimental considerations, methods, and preliminary findings of two public datasets created by our team, one for short-term and another for long-term assessment, with ECG data collected at the hand palms and fingers. 相似文献
86.
Marta Lubary Gerard W. Hofland Joop H. ter Horst 《European Journal of Lipid Science and Technology》2011,113(4):459-468
We propose a novel process for the production of a DAG‐rich acylglycerol mixture derived from milk fat. This product has potentially interesting nutritional properties, derived from both its high content of DAG and of short‐chain fatty acids (FAs). The proposed process consists of three steps: lipase‐catalysed partial ethanolysis of milk fat, extraction of the by‐product fatty acid ethyl esters (FAEEs) using supercritical carbon dioxide (SC‐CO2) and isomerization of DAG to increase the proportion of 1,3‐DAG. The experimental investigation of the process steps was done using milk fat and trilaurin. Several lipases were tested for maximizing the percentage of DAG in the acylglycerol mixture produced by ethanolysis. The selectivity of the chosen lipase was such that the produced AG mixture was enriched in short‐chain FAs in relation to the original milk fat. FAEEs were completely extracted from the ethanolysis mixture by SC‐CO2. In the final process step, we explored the reaction conditions for facilitating acyl migration in the DAG mixture, so that the equilibrium proportion of 1,3‐DAG (~64%) was attained. Our results set the basis for the development of a simple process for the production of a DAG‐rich milk fat analogue. 相似文献
87.
Rheokinetic model to characterize the maturation process of gelatin solutions under shear flow 总被引:1,自引:0,他引:1
The characterization of maturing gelatin solutions in shear flow is required for an appropriate formulation of food products. Under static conditions, the maturation process of gelatin solutions may be described through a basic structural parameter evolving to the percolation value (gel point). Within the rheological framework, two asymptotic viscosities are well identified for the maturing process of gelatin solutions at the limit zero shear rate. One involves the initial solution viscosity that may be associated with the null structural parameter (the microstructure is not formed yet). The other is the percolation zero shear rate viscosity (assuming an infinite value when approaching the gel time) and corresponds to the maximum value of the structural parameter. Under flow, thixotropic theories combined with the knowledge of suspension rheology allow one to convert directly experimental data obtained as shear stress versus time for a given shear rate into the time evolution of the structural parameter. Consequently rheometric experimental data available places the search for a rheokinetic model of the structural parameter. Here, different expressions for this model are investigated, mainly those involving both the rates of structure breakdown and buildup, where the average cluster size is affected by the shear rate. The rate equation thus obtained may be then applied to arbitrary shear rate histories. Numerical results of the rheokinetic model proposed in this work fit well experimental rheometric data obtained in shear flow for the maturing of different gelatin solutions. Experimental data acquired in this work are presented and discussed in relation to those reported previously in the literature. 相似文献
88.
Witold Gładkowski Grzegorz Kiełbowicz Anna Chojnacka Marta Gil Tadeusz Trziszka Zbigniew Dobrzański Czesław Wawrzeńczyk 《Food chemistry》2011
The effect of feed supplementation with humic-fat preparations on the fatty acid composition of egg yolk phospholipid fractions was studied. The Lohmann Brown was the experimental hen strain and two feeding mixtures were applied – the standard feed and the mixture supplemented with humic-fat preparations. The fatty acid profile of yolk lipids was significantly affected (P = .05) by the supplementation of feed and total increase of n-3 polyunsaturated fatty acids (PUFA) was established. A different distribution of n-3 PUFA in egg yolk lipid fractions was observed: α-linolenic acid (18:3) was found in the triacylglycerol fraction, whereas docosahexaenoic acid (22:6) was detected in the phospholipid fractions. Supplementation of the hen’s diet with humic-fat preparations resulted in the production of n-3 enriched eggs with decreased n-6/n-3 ratio in all phospholipid fractions in comparison to the eggs from the control group. 相似文献
89.
Marta S. P. Silva Alírio E. Rodrigues José P. B. Mota 《American Institute of Chemical Engineers》2015,61(4):1345-1363
The Parex unit for industrial‐scale purification of p‐xylene was studied through detailed simulation and the accuracy of the developed model tested against real industrial data. Starting from a comprehensive analysis of the construction and operation of the industrial unit, a simulation model was developed that incorporates the existing three major types of dead volumes: bed lines, which connect the beds to the rotary valve, circulation lines, which connect adjacent adsorbent chambers, and bed‐head dead volumes, which are located upstream of each bed due to the existence of internals. By gathering operation data and surveys in the pumparound line and in the extract stream, three case studies were defined and compared with simulation results. The model is capable of predicting the performance of the industrial unit. Further simulations were made and compared with plant data to assess the effect of adsorbent capacity loss on the long‐term performance of the unit. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1345–1363, 2015 相似文献
90.
Nishant Singh Marta Tena-Solsona Juan F. Miravet Beatriu Escuder 《Israel journal of chemistry》2015,55(6-7):711-723
Self-assembly of small peptides offers unique opportunities for the bottom-up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information-rich, simple molecules based on amino acids can self-organise autonomously into complex systems with emergent catalytic properties. The power of noncovalent interactions can be used to construct supramolecular peptidic tertiary structures. Moreover, specific functional groups present in amino acid side-chains may present either a catalytic activity by themselves or be able to bind cofactors such as metal ions. In this scenario, although relevant progress has been achieved in recent years, promising applications in biomaterials science are foreseen. In this review, we discuss the state-of-the-art of this approach at the interface between supramolecular chemistry and peptide science. 相似文献